Malignant lymphoma is a neoplasm which originates in lymph tissue. It is not actually breast cancer, but can be difficult to distinguish from breast cancer in the early stages of disease. The early breast cancer screening mammography indicators for potentially malignant breast cancer are quite similar to malignant lymphoma, and as a result, malignant lymphoma of the breast is often unexpected, when the biopsy result comes back.
A primary non-Hodgkin’s lymphoma of the breast is a very rare occurrence, accounting for only about 0.1 to 0.5 % of all reported malignant breast tumors. Most patients who develop primary breast lymphoma will also develop metastasis to other regions of the body.
There are various kinds of lymphomas, but the most common breast lymphoma is the B cell non-Hodgkin’s lymphoma. In terms of clinical prognosis, an early diagnosis of a low grade or stage I lymphoma will generally give the best outlook.
Breast lymphoma mostly affects older women
A majority of patients with breast lymphoma present with a localized intermediate-grade lymphoma, and most cases presenting with disseminated disease actually have a low-grade lymphoma. On average, patients presenting with breast lymphomas are split between stage I and stage II tumors about 50% of the time. The average age of development for a breast lymphoma seems to be about 57 years. Lymphoma of the breast can develop in a younger women, but on the whole it is a disease that mostly affects older women.
Clinical and mammographic presentation of breast lymphomas
In the clinical setting, a breast lymphoma might present as elastically firm, well-defined, and often multiple tumors. There might be other symptoms going on in other areas of the body, however.
A women with lymphoma might also present with some enlarged lymph nodes in her neck or armpits.
The most common symptoms of breast lymphoma are a painless breast mass, most frequently located in the outer quadrants ( and usually in the right breast, for some reason)
Breast lymphomas rarely show microcalcifications
Ultrasound of breast lymphomas tends to be of a hypoechoic lobulated mass
An ultrasound of lymphoma of the breast might typically reveal a coarse internal echo, a hypoechoic mass with an irregular border and occasionally a lobulated mass representing a very large tumor. The most likely ultrasound image for a breast lymphoma will be of a heterogeneous lobulated hypoechoic mass.
Sometimes MRI can help detect a malignant breast lymphoma. A primary breast MRI is often visualized as a lobulated lesion with expansive and infiltrating features. However, breast MRI findings on lymphomas are quite non-specific. Still, breast MRI can help in the diagnosis and treatment of a breast lymphomas in that it can help determine the extent and number of lesions, and in finding any cutaneous, subcutaneous or nodal involvement of the contralateral breast.
Breast lymphoma imaging cannot predict histology
Although the various imaging characteristics of a given breast tumor may suggest the possibility of breast non-Hodgkin’s lymphoma of the breast, none of the findings are pathognomonic. The imaging pattern of breast lymphoma is unrelated to its histopathologic subtype, and in fact, only a very small number of patients ultimately diagnosed with lymphoma of the breast actually present with clear B-cell lymphoma symptoms.
Histological aspects of lymphoma of the breast
Histologically, breast lymphoma-tumors tend to infiltrate between mammary ducts, but do not tend to destroy them. Interestingly, it is actually quite difficult to distinguish malignant breast lymphoma from breast in the early stages, even when examining excisional biopsy and fine needle biopsy samples. Only when the disease really takes hold and one finds the clear presence of diffuse large B-cells can one make a definitive diagnosis. Most breast lymphomas are initially diagnosed as breast carcinoma, because that is what they appear to be. It usually takes a really high-power microscopic view to see the B-cells of breast lymphoma in evidence. When they are present, one might typically see an abnormal lymphoid population of small to medium sized centrocyte-like B-cells and monocytoid B-cells.
Treatment options for breast lymphomas
The therapeutic management of breast lymphoma is not as fully established as the treatment options for breast cancer, and some aspects remain a bit controversial. The first treatment priority for breast lymphoma is of course to determine whether the disease originates in the breast, or is systemic in nature. There are many different kinds of lymphoma, too many to be discussed here, but the kinds of lymphoma that form soft tissue masses in unusual locations such as the breast are generally more problematic to treat. However, there is usually some positive response to treatment.
Treatment is similar to breast cancer
The three main options for treatment are similar to breast cancers. Patients are usually treated either by surgical intervention alone (for localized breast tumors), surgery with chemotherapy, or surgery with radiation therapy and chemotherapy, a so-called multi-modal approach. Quite often, chemotherapy is withheld until there is evidence of a relapse, or, until there is evidence that the lymphoma is systemic in nature. Some breast lymphomas may be treated without surgery and just with radiation therapy, and these tumors do tend to have the best prognosis, likely because the presentation was mild enough and found early enough that surgery and chemical therapy were not indicated.
Stem cell transplantation is sometimes used
Another intensive treatment option for breast lymphoma, should circumstances indicate, is to include high-dose chemotherapy supported by peripheral blood stem cell transplantation, but the use of stem cells is very controversial and not widely discussed. Essentially what happens in these more intensive types of treatment is that first a bone marrow sample is taken. Then, the physicians attempt to grow stems cells from the bone marrow in a laboratory setting. In the chemical treatment of the breast lymphoma, the lymphoma is ‘poisoned’, which kills it, but this will often kill the patient’s bone marrow as well. So, the doctors may then attempt to ‘rescue’ the damaged bone marrow by putting the saved sample, along with the newly grown stem cells, back into the patient.
Prognosis for lymphoma of the breast
Overall, breast lymphoma has a poor prognosis, and while there is still a good deal of success, the disease-free recover rates are in general quite a bit lower than for breast cancer. Without any kind of adjuvant therapy, the relapse rate for breast lymphomas treated by surgery alone is fairly high, and relapse can even occur up to ten years following breast surgery. However, no discernible factors, including stage or histologic findings, appear to consistently effect the recurrence rate. But generally, if a patient survives the early treatment phase of the disease, they tend to do very well.
Most breast lymphomas are treated with surgery and chemotherapy
Statistically, it would seem that about 35% of patients with lymphoma of the breast are treated by surgery and chemotherapy , and about 36% treated with surgery and chemotherapy and radiation, and about 20% treated by surgery with radiation. A smaller percentage, about 6%, are treated with surgery alone, and another very small subgroup is treated by radiation therapy alone.
About 1/2 of breast lymphomas go into remission
The rates of complete remission of lymphoma of the breast tend to be around the 50% range, with a slightly higher success ratio for patients treated with surgery and chemotherapy. (Statistics regarding the success rates for different treatment modalities tend to be quite variable- the average success rates are about the same, but the ‘best’ treatment methods are not consistently demonstrated across many studies.) However, it must be remembered that the choice of treatment will usually depend upon many circumstances, including the health of the patient and the severity of the disease at the time of presentation.
Warning. This page is a little old, and the survival information in the next paragraphs is old. Survival rates are much better than when this page was originally created. However we have a full index of up-to-date posts on survival rates HERE
Unfortunately, the survival rates for breast lymphoma are not all that promising. It can be estimated that about 30% to 50% of patients with lymphoma of the breast will survive beyond two years. The overall survival rates are slightly higher for patients treated with surgery and radiation therapy without chemotherapy, but one cautions that the use of chemotherapy is usually indicated when the disease is already at a more advanced or systemic state, so those statistics can be misleading. However, it does appear that for patients who succumb to the disease, closure tends to occur in an average for seven months or so rather than a prolonged battle. So, if a patient with breast survival can survive beyond one to two years, chances are that the disease is in remission.
Prognosis for stage I lymphomas is much higher
Generally speaking, the prognosis for breast lymphoma seems to be related to the histologic type and stage of the disease. If a breast lymphoma is graded as stage II, then the overall survival rates seem to be just below 30%, while the prognosis for stage I tumors is much better, with overall survival rates or ‘freedom from probable progression’ around 60%.
- Suzuki Y, Tokuda Y, Okumura A, Saito Y, Ohta M, Kubota M, Makuuchi H, Tajima T, Umemura S, Osamura RY. Three cases of malignant lymphoma of the breast. Jpn J Clin Oncol. 2000 Jan;30(1):33-6.
- Hasegawa S, Kosaka A, Mori I. A case of primary malignant lymphoma of the breast. Nippon Rinsyo Geka Igakukai Zasshi 1995;56:519–23
- Mammbo NC, Burke JS, Butler JJ. Primary malignant lymphomas of the breast. Cancer 1977;39:2033–40.
- Wiseman C, Liao KT. Primary lymphoma of the breast. Cancer 1972;29:1705–12.
- DeCosse JJ, Berg JW, Fracchia AA, Farrow JH. Primary lymphosarcoma of the breast. A review of 14 cases. Cancer 1962;15:1264–8.
- Tokuda Y, Ohta M, Okumura A, Kuge S, Kubota M, Tajima T, et al. High-dose chemotherapy with autologous hematopoietic stem-cell transplantation in breast cancer. Cancer Chemother Pharmacol 1997;40:94–9
- Giardini R, Piccolo C, Rilke F. Primary non-Hodgkin’s lymphoma of the female breast. Cancer 1992;69:725–35.
- Wong WW, Schild SE, Halyard MY, Schomberg PJ. Primary non-Hodgkin lymphoma of the breast: the Mayo Clinic experience. J Surg Oncol. 2002;80:19-25.
- Domchek SM, Hecht JL, Fleming MD, Pinkus GS, Canellos GP. Lymphomas of the breast. Cancer. 2002;94:6-13.
- Zack JR, Trevisan SG, Gupta M.Primary breast lymphoma originating in a benign intramammary lymph node. AJR Am J Roentgenol. 2001 Jul;177(1):177-8.
- Brustein, S., filippa, DA., Kimmel, M., Lieberman, PH., Rosen, PP. Malignant lymphoma of the breast. A study of 53 patients.Ann Surg. 1987 February; 205(2): 144–150.
- Garg NK, Bagul NB, Rubin G, Shah EF.Primary lymphoma of the breast involving both axillae with bilateral breast carcinoma.World J Surg Oncol. 2008 May 20;6:52.
- Darnell A, Gallardo X, Sentis M, Castaner E, Fernandez E, Villajos M: Primary lymphoma of the breast: MR imaging features. A case report. Magn Reson Imaging 1999 , 17(3):479-482
- Oliveira A, Guimaraes T, Bento MJ, Viseu F, Silva I: Primary non-Hodgkin’s lymphoma of the breast.Ann Oncol 2000 , 11(Supplement 4):103.
- Mattia AR, Ferry JA, Haris NL: Breast lymphoma. A B-cell spectrum including the low grade B-cell lymphoma of mucosa associated lymphoid tissue. Am J Surg Pathol 1993 , 17:574-587.
- Pinheiro RF, Colleoni GW, Baiocchi OC, Kerbauy FR, Duarte LC, Bordin JO: Primary breast lymphoma: an uncommon but curable disease. Leuk Lymphoma 2003 , 10():519-520.
- Jackson FI, Zulfikarli H, Lalani ZH: Breast lymphoma: radiologic imaging and clinical appearances.Can Assoc Radiol J 1991 , 42:48-54.
- Liberman L, Giess CS, Dershaw DD, Louie DD, Deutch BM: Non-Hodgkin’s lymphoma of the breast: imaging characteristics and correlation with histopathologic finding. Radiology 1994 , 192:157-160.
- Jeanneret-Sozzi W, Taghian A, Epelbaum R, Poortmans P, Zwahlen D, Amsler B, Villette S, Belkacémi Y, Nguyen T, Scalliet P, Maingon P, Gutiérrez C, Gastelblum P, Krengli M, Raad RA, Ozsahin M, Mirimanoff RO. Primary breast lymphoma: patient profile, outcome and prognostic factors. A multicentre Rare Cancer Network study. BMC Cancer. 2008 Apr 1;8:86.
- Topalovski M, Cristan D, Mattson JC: Lymphoma of the breast: a clinicopathologic study of primary and secondary cases. Arch Pathol Lab Med 1999 , 123:1208-1218
- Brogi E, Harris NL: Lymphomas of the breast: pathology and clinical behavior. Semin Oncol 1999 , 26:357-364.
- Ribrag V, Bibeau F, El Weshi A, Freyfer J, Fadd C, Cebotaru C, Laribi K, Fenaux P: Primary breast lymphoma: a report of 20 cases.Br J Haematol 2001 , 115:253-256
- Huang DZ, He XH, Yang S, Shi YK: Clinical and pathological analysis of 15 cases of primary breast lymphoma. Ai Zheng 2004 , 23:939-942.
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