Breast adenocarcinoma with spindle cell metaplasia
Breast adenocarcinoma with spindle cell metaplasia is essentially an invasive adenocarcinoma of the breast but with abundant spindle cell transformation. These spindle cells are glandular in origin and not squamous or mesenchymal. A breast cancer tumor might be diagnosed as adenocarcinoma with spindle cell metaplasia if most of the tumor are composed of spindle cells.
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Breast adenocarcinoma with spindle cell metaplasia is a subtype of epithelial metaplastic breast carcinoma. Metaplastic breast carcinomas are rare primary breast malignancies which are characterized by the co-existence of carcinoma (epithelial) with non-epithelial cellular elements.
They are often sub-classified as biphasic carcinosarcoma, monophasic spindle cell (sarcomatoid) carcinoma, adenocarcinoma with stromal differentiation (osseous, chondroid and rarely rhabdoid), and also as adenosquamous and pure squamous cell carcinoma.
Tumors are often positive for epidermal growth factor
Cytologically, a breast adenocarcinoma with spindle cell metaplasia will tend to be composed of tubules of adenocarcinoma mixed up with neoplastic spindle cells. The spindle cells will typically be immunoreactive for epithelial markers, including CK7, but not with some other common CK markers and not with markers of squamous or myoepithelial differentiation.
The spindle cells will usually contain intracytoplasmic lumens, which confirms an essentially glandular population of cells. A breast adenocarcinoma with spindle cell metaplasia will also tend to test positive for EPGR or epidermal growth factors.
A breast adenocarcinoma with spindle cell metaplasia will occur more commonly in postmenopausal women, and usually does present as a discrete mass. The clinical presentation of breast adenocarcinoma with spindle cell metaplasia will be similar to that of infiltrating duct carcinoma, but microcalcifications are uncommon on mammography.
Usually treated with surgery, radiation, and chemotherapy
Treatment of breast Adenocarcinoma with spindle cell metaplasia usually involves local excision or mastectomy, and chemical and radiation therapy are commonly used as adjuvant therapies.
- What are the treatments for invasive adenocarcinoma of the breast? Breast cancer surgery, chemotherapy, or radiation treatment.
- What are the two main types of adenocarcinoma? Ductal carcinomas and lobular carcinomas are the two most common types.
- Where does adenocarcinoma start? It starts in the ducts or lobules of the breast.
- Spindle cell carcinoma treatment – Surgical removal, cryotherapy, radiotherapy, hormone therapy, and chemotherapy. These treatments are chosen independently depending on the location and the size of the tumor. They may also be combined together for better results.
- What causes spindle cell carcinoma? Injury and inflammation in patients that are already thought to be predisposed to such tumors.
- Spindle cell carcinoma symptoms – Fatigue, malaise and mild dizziness.
- What are spindle cell tumors? How to treat them? They are going to receive the same treatment as other types, and the prognosis is similar.
- Yamazaki, K., Kazuno, K. Kajiura, Y., Sato, K., Ozawa, K., Sugimoto, H., Tokushashi, Y., Sugano, H., Sasajima, T., A case of adenocarcinoma with spindle cell metaplasia of the breast. Hokkaido Journal of Surgery(2000).
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